Coiled-coil domain-containing protein 184 (CCDC184)

Coiled-coil domain-containing protein 184 is a human protein encoded by the CCDC184 gene; it consists of 194 amino acids and includes a domain of unknown function (DUF4677)[2]. Its primary molecular function is protein binding. CCDC184 is broadly and highly expressed in the brain, especially in regions such as the hypothalamus, pons, and pituitary gland[2][12]. Single-cell transcriptomics suggest CCDC184 is highly expressed in postmitotic interneurons and correlated with genes for cell-cell adhesion, indicating possible roles in neuronal migration and morphological differentiation, particularly through potential interactions with cadherin family proteins[5]. Predicted post-translational modifications include phosphorylation, SUMOylation, myristoylation, and acetylation[2]. CCDC184 is found only in mammals and is localized to the cytoplasm[2][3]. Despite associations with certain disease states (e.g., breast cancer tissue studies, arrhythmogenic right ventricular cardiomyopathy), it is not considered a validated therapeutic target, and its detailed molecular function remains uncharacterized[2][4][5].

Other names

CCDC184C12orf68LOC387856Coiled-coil domain-containing protein 184