Coiled-coil domain-containing protein 185 (CCDC185)

Coiled-coil domain-containing protein 185 (CCDC185) is a protein-coding gene located on human chromosome 1[1][8][9]. It encodes a protein characterized by the presence of a coiled-coil structural domain, which is typical of proteins involved in a variety of protein-protein interactions[13]. Functionally, CCDC185 has been implicated in several cellular processes, including the regulation of GTPase activity, intracellular protein transport, and the negative regulation of cilium assembly[5]. The gene is ubiquitously expressed at the RNA level in a range of tissues, but its precise physiological or pathological roles remain unclear[11]. Disease associations reported in databases are preliminary and include links to dystonia 23 and complete androgen insensitivity syndrome, but there is no strong evidence placing CCDC185 as a central actor in these conditions[9]. There are currently no known drugs that directly target CCDC185, nor is it classified in major molecular families such as enzymes, receptors, or ion channels; instead it is considered part of the broad class of "other" coiled-coil domain proteins[1][3][13].\n\nNo evidence places CCDC185 as a therapeutic target, nor is it reported to serve as a clinical biomarker or to be associated with specific safety or therapeutic concerns.

Other names

CCDC185C1orf65FLJ35728coiled-coil domain containing 185chromosome 1 open reading frame 654922505E12Rik