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Coiled-coil domain-containing protein 191 (CCDC191)
- Target
- CCDC191
- Molecular classification
- Other (coiled-coil domain protein), Centrosome-associated contractile fiber protein
01
Overview
Coiled-coil domain-containing protein 191 (CCDC191) is a protein encoded by the CCDC191 gene. Predicted to have binding activity with phosphatases and potentially associated with centrosomal contractile fiber structures, its precise biological function remains largely uncharacterized[1][6]. Bioinformatics and computational studies suggest it is a context-dependent regulator in cancer, possibly acting as a “double agent” with both oncogenic and tumor-suppressor roles depending on tumor type and signaling context, such as the PI3K pathway in breast cancer[2]. High expression of CCDC191 is associated with improved prognosis in bladder urothelial carcinoma patients, indicating a possible prognostic biomarker role[2]. No known drugs target CCDC191 directly, and it is not regarded as a validated therapeutic target as of current knowledge[1][2][6].
- Other names
- KIAA1407coiled-coil domain containing 191CCDC191
02
Mechanism of action
Not applicable/unknown
03
Biological functions
Putative phosphatase bindingpossible roles in cell fate determinationcell survivalgenome maintenancepossible RNA metabolism and nucleic acid metabolism functionmay act as a “double agent” in cancer with both tumor-suppressor and oncogenic rolesinvolvement in breast cancer estrogen/progesterone receptor signaling pathways
04
Disease associations
Cancer (notably breast cancer, bladder cancer; associated with epulis)potential prognostic marker in bladder cancer
05
Biomarkers
CCDC191 expression level may serve as a prognostic biomarker in bladder urothelial carcinoma and may be related to ER+/PR+ breast cancer
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