Coiled-coil domain-containing protein 196 (CCDC196)

Coiled-coil domain-containing protein 196 (CCDC196) is a human protein encoded by the CCDC196 gene (aliases include C14orf53, LINC00238, NCRNA00238)[4][9][10]. As part of the broad CCDC protein family, CCDC196 contains a coiled-coil domain—a structural motif typical for mediating protein-protein interactions, with an implication that it may be involved as a component of larger protein complexes[1]. While coiled-coil domain-containing proteins are implicated in diverse processes such as development, signaling, and disease, the precise biological function of CCDC196 specifically is unknown and not well characterized experimentally[2][13]. Recent genomics data annotate its gene as protein-coding[6][9], but some transcript aliases (such as LINC00238, NCRNA00238) may refer to long intergenic non-coding RNA variants. The gene has been associated with hepatocellular carcinoma and glioma susceptibility, but the causative or functional mechanisms remain unconfirmed in the literature[9][11]. No known drugs target this protein, and it is not considered a therapeutic target or biomarker based on current evidence.

Other names

C14orf53LINC00238NCRNA00238long intergenic non-protein coding RNA 238