Coiled-coil domain-containing protein 32 (CCDC32)

Coiled-coil domain-containing protein 32 (CCDC32) is a protein encoded by the CCDC32 gene, implicated in the assembly of adaptor protein complex 2 (AP2), crucial for clathrin-mediated endocytosis in eukaryotic cells[1]. CCDC32 acts as a selective and essential assembly chaperone, specifically regulating the formation of the AP2 adaptor complex via interaction with its α, σ2, and μ2 subunits, facilitating correct assembly sequence and stability[1]. Additionally, CCDC32 has an evolutionarily conserved role in ciliogenesis, being required for the formation and/or maintenance of cilia necessary for vertebrate left-right axis development. Loss-of-function mutations in CCDC32 are linked to congenital syndromes characterized by craniofacial, cardiac, and neurodevelopmental defects[2]. While it interacts with annexin A2, the broader molecular role remains incompletely defined[2]. There are currently no approved drugs, known mechanisms of drug targeting, validated biomarkers, or explicit safety concerns associated with CCDC32.

Other names

CCDC32C15orf57MGC20481CFNDSuncharacterized protein C15orf57