Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Coiled-coil domain-containing protein 63 (CCDC63)
- Target
- CCDC63
- Molecular classification
- Other, Structural protein (coiled-coil domain-containing protein)
01
Overview
Coiled-coil domain-containing protein 63 (CCDC63) is a structural protein involved in the formation and function of sperm flagella, and plays a significant role in spermiogenesis, including elongation of flagella and the formation of sperm heads. It is predicted to be active in the axoneme, the structural core of cilia and flagella. Genetic variants in CCDC63 have been implicated in several conditions, including primary ciliary dyskinesia, reticular dysgenesis, and metabolic syndromes, with additional genome-wide association data suggesting possible roles in metabolic regulation, alcohol consumption behavior, and reproductive development. Despite these genetic associations, there is no evidence in current sources that CCDC63 is a direct therapeutic target or that any drugs interact with it[2][3][4][7][8][9][11].
- Other names
- ODA5FLJ35843outer row dynein assembly 5 homologCCD63_HUMAN
02
Biological functions
Cilium movementOuter dynein arm assemblySpermatid developmentSpermiogenesisElongation of flagellaFormation of sperm heads
03
Disease associations
Primary ciliary dyskinesiaReticular dysgenesisMetabolic syndrome (genetic association)Type 2 diabetes mellitus (genetic association)Other (reproductive disorders, candidate sex-determining gene in some species)
Beyond the preview
Go deeper on Coiled-coil domain-containing protein 63 (CCDC63).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Coiled-coil domain-containing protein 63 (CCDC63).