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Target intelligence / Profile preview
Coiled-coil domain-containing protein 66 (CCDC66)
- Target
- CCDC66
- Molecular classification
- Other, Microtubule-associated protein
01
Overview
Coiled-coil domain-containing protein 66 (CCDC66) is a highly conserved microtubule-associated protein that regulates cilium assembly, maintenance, and disassembly and is required for proper ciliary signaling and epithelial organization[1][4]. CCDC66 localizes to the ciliary axoneme, centrosome, centriolar satellites, and spindle apparatus during mitosis, where it regulates microtubule organization and nucleation, as well as actin cytoskeleton interactions[1][2][3][4][5]. Mutations or loss of CCDC66 are linked to defects in ciliary function, ciliopathies such as Joubert syndrome, and retinal degeneration, highlighting its essential role in cytoskeletal processes and cell division[1][4][5]. There are no known small-molecule drugs or therapeutic modulators currently reported to interact specifically with CCDC66 in a clinical setting[4].
- Other names
- DKFZp686C0433CCDC66
02
Biological functions
Cilium assembly and maintenanceCilium disassemblyRegulation of cilium length and signalingMicrotubule bundle formation and stabilizationRegulation of protein localization to ciliumSpindle assembly and organization during mitosisCytokinesisCell polarity and epithelial organization
03
Disease associations
Ciliopathies (including Joubert syndrome)Retinal degenerationMyopiaBardet-Biedl syndrome (by association)
04
Safety considerations
Currently, safety/therapeutic challenges are largely genetic, relating to loss-of-function mutations causing ciliopathies and retinal degeneration but not to drug targeting[1][4][5].
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