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Coiled-coil domain-containing protein 71L (CCDC71L)
- Target
- CCDC71L
- Molecular classification
- Other (Coiled-coil domain-containing protein; not a canonical receptor, enzyme, transporter, transcription factor, or channel by current standard annotations)
01
Overview
Coiled-coil domain-containing protein 71L (CCDC71L) is a protein encoded by the CCDC71L gene in humans. It is characterized by a coiled-coil structural motif but does not belong to a major drug target class such as receptors or enzymes. CCDC71L plays a functional role in processes such as cellular lipid metabolism, cell proliferation, migration, and apoptosis inhibition. Recent genetic studies link it to both cancer progression (e.g., triple-negative breast cancer and head and neck squamous cell carcinoma) and cardiovascular traits (e.g., megakaryopoiesis, platelet production, and atherosclerotic plaque formation). It has been identified as a biomarker of poor prognosis in head and neck squamous cell carcinoma and may be related to immune infiltration and genome heterogeneity in tumors, suggesting potential as a prognostic biomarker and a research target for immunotherapy or cancer biology. However, no approved therapeutics currently target CCDC71L directly.
- Other names
- C7orf74FLJ36031coiled-coil domain containing 71 likeCCDC71L
02
Biological functions
Lipid metabolismCellular proliferationCell migration and invasionApoptosis inhibitionPlatelet production/megakaryopoiesis
03
Disease associations
Cancer (notably head and neck squamous cell carcinoma and triple-negative breast cancer)Cardiovascular disease (subclinical atherosclerosis)
04
Biomarkers
Expression level of CCDC71L for prognosis in head and neck squamous cell carcinomaPotential biomarker for disease aggressiveness in triple-negative breast cancer
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