Coiled-coil domain-containing protein 74B (CCDC74B)

Coiled-coil domain-containing protein 74B (CCDC74B) is a microtubule-associated protein that localizes to the mitotic spindle, directly binding and bundling microtubules via two distinct domains[1][3]. This ability is critical for the organization and stabilization of kinetochore fibers (K-fibers), the formation of bipolar spindles, and the correct alignment of chromosomes during mitosis. CCDC74B self-associates as a homodimer, a property essential for its microtubule bundling activity[1]. High-throughput proteomics indicate it participates in broader protein-protein interaction networks but there is no direct evidence linking it to drug response or established disease mechanisms. Its expression is detectable in multiple cancer tissues, but it is not currently a validated therapeutic target or clinical biomarker[1][5]. This is a microtubule-associated structural and regulatory protein important for mitotic spindle function and chromosome segregation. It is not an established therapeutic target or biomarker, and no drugs or safety information are associated with it at this time.

Other names

Coiled-coil domain containing 74BDKFZp434E2321CC74B_HUMAN