Coiled-coil domain-containing protein 85A (CCDC85A)

Coiled-coil domain-containing protein 85A (CCDC85A) is a member of the delta-interacting protein A (DIPA) family and encodes a protein characterized by coiled-coil motifs[1]. It is localized mainly at adherens junctions and the endoplasmic reticulum, where it interacts with proteins of the beta-catenin family and molecular chaperones such as GRP78 and GRP94[1][3][7]. CCDC85A modulates cell-cell adhesion, possibly epithelium development, and regulates the cellular response to ER stress by sustaining activation of the PERK pathway, facilitating cancer cell migration and invasiveness, and protecting cells from ER stress-induced apoptosis. High expression is linked to increased cancer cell resistance to drugs like cisplatin and may act as a mediator of tumor microenvironment adaptation[1][3][7]. Its regulation by miR-224-3p and possible detection in tumor fibroblasts and cancer cells also identifies CCDC85A as a possible biomarker and a candidate cellular target for overcoming drug resistance in oncology[1].

Other names

CCDC85AKIAA1912coiled-coil domain containing 85Acoiled-coil domain-containing protein 85ADIPA (delta-interacting protein A family member)

Not a direct pharmacological target, but modulation (e.g., by miR-224-3p or via exosomes) influences ER stress response and cisplatin resistance in cancer cells[1].