Target intelligence / Profile preview

Coiled-coil domain-containing protein 85C (CCDC85C)

Target
CCDC85C
Molecular classification
Other (Coiled-coil domain-containing protein; not a receptor, enzyme, transporter, or major signaling class)
01

Overview

Coiled-coil domain-containing protein 85C (CCDC85C) is a human protein encoded by the CCDC85C gene. It is predicted to be involved in cerebral cortex development, the Notch signaling pathway, establishment of cell polarity, and radial glial cell differentiation. CCDC85C is localized to adherens junctions and may play a role in cell-cell adhesion and epithelium development, possibly through interactions with proteins of the beta-catenin family. Clinically, variations in CCDC85C are associated with congenital disorders of glycosylation and pontocerebellar hypoplasia. CCDC85C is not currently recognized as a drug target, with no known interacting drugs or established safety concerns or biomarker roles[1][4][9][10][11].

Other names
C14orf136EG668158Gm265Gm9010hhyLOC100128667LOC684166coiled-coil domain containing 85C
02

Biological functions

Cerebral cortex developmentNotch signaling pathway regulationEstablishment of cell polarityRadial glial cell differentiationCell-cell adhesionEpithelium development
03

Disease associations

Congenital disorder of glycosylation, type IIcPontocerebellar hypoplasia, type 3

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