Coiled-coil domain-containing protein 92 (CCDC92)

Coiled-coil domain-containing protein 92 (CCDC92) is a ubiquitously expressed nuclear protein in humans, with a conserved coiled-coil domain of unknown specific function[1]. CCDC92 is predicted to participate in DNA repair and redox reactions and is induced by interferon, strongly inhibiting ebolavirus transcription and replication, indicating a role in the innate immune response[2][4]. Experimental data show CCDC92 regulates cholesterol metabolism and podocyte injury in the kidney by binding to the proteasome activator PA28α, promoting degradation of the cholesterol transporter ABCA1 via the proteasome, thus impacting cholesterol efflux and podocyte health in diabetic kidney disease[3]. In reproductive biology, CCDC92 is essential during spermiogenesis, regulating sperm head and tail formation via interactions with intraflagellar transport complex proteins in the developing spermatid manchette; loss of CCDC92 causes male infertility in model organisms[5]. There are no approved direct therapeutic agents acting on CCDC92, though expression is increased by certain epigenetic and kinase inhibitors, suggesting CCDC92 might influence cellular repair and drug responses in some cancer and disease contexts[1].

Other names

Limkain beta-2FLJ22471limkain beta 2coiled-coil domain containing 92CCDC92

Not directly targeted by drugs, but upregulation by epigenetic and kinase inhibitors may increase DNA repair capacity; proteasome inhibitors counteract CCDC92-linked podocyte injury by stabilizing ABCA1 protein via anti-proteasomal effect