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Coiled-coil-helix-coiled-coil-helix domain containing 1 (CHCHD1)
- Target
- CHCHD1
- Molecular classification
- Mitochondrial ribosomal protein (specifically small subunit - MRPS37), Protein coding gene, Other: RNA-binding protein
01
Overview
Coiled-coil-helix-coiled-coil-helix domain containing 1 (CHCHD1) is a mitochondrial ribosomal protein of the small subunit (MRPS37). It participates in mitochondrial translation, essential for the synthesis of proteins encoded by mitochondrial DNA. Mutations and defects in mitochondrial ribosomal proteins, including CHCHD1, can result in disorders of mitochondrial function leading to diseases such as combined oxidative phosphorylation deficiency. It is not a classic therapeutic target (receptor, enzyme, transporter) but is essential for normal mitochondrial function and energy metabolism in cells
- Other names
- CHCHD1MRP-S37mS371110001O19Rik2400010G13RikC10orf34C2360
02
Mechanism of action
Not applicable. Since no drugs are reported to interact, mechanisms of action for drug-target interactions are not described
03
Biological functions
Mitochondrial translation (essential for mitochondrial protein synthesis)RNA bindingProtein bindingCellular localization: mitochondrion, cytosol, nuclear lumen
04
Disease associations
Mitochondrial complex IV deficiency, nuclear type 6Combined oxidative phosphorylation deficiency 1Dysfunction of mitochondrial translation can impact diseases related to mitochondrial function
05
Safety considerations
None known specifically related to therapeutic targeting, as it is not targeted by drugs.Given its essential role in mitochondrial protein synthesis, modulation could theoretically impair cellular energy metabolism, but this is not a current therapeutic challenge
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