Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (CHCHD2)

Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (CHCHD2) is a nuclear-encoded mitochondrial protein involved in the regulation of mitochondrial electron transport and morphology, apoptosis inhibition, transcriptional adaptation to hypoxia, and cellular migration and differentiation[1][2][4][5][6][7]. It contains a conserved CHCH domain defined by cysteine linkages and translocates between the mitochondrial intermembrane space and the nucleus in response to cellular stress. Mutations or dysregulation of CHCHD2 are linked to neurodegenerative diseases such as Parkinson’s, and overexpression in cancers like NSCLC is associated with poor prognosis and enhanced hypoxia signaling[3][4]. It interacts with mitochondrial proteins such as cytochrome c, MICS1, and OPA1, and modulates apoptosis by antagonizing Bax function[1][2][5]. CHCHD2 is considered a potential therapeutic target, but no specific drugs have yet been approved to modulate its activity directly[3][4].

Other names

MNRR1C7orf17NS2TPAging-associated gene 10 proteinMIX17 homolog BPARK2216.7kD proteinCoiled-coil-helix-coiled-coil-helix domain containing 2