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COL25A1 divergent transcript (COL25A1-DT) is annotated as a noncoding RNA gene, distinct from the protein-coding collagen type XXV alpha 1 chain (COL25A1). It has also been referred to by the alias ZCCHC23 due to predicted zinc finger CCHC domain sequence features. The transcript is predicted to possess nucleic acid-binding and zinc ion-binding functions, based primarily on computational analysis, but there is no experimental evidence supporting a molecular function, biological role, pathological association, or relevance as a therapeutic target. It is not a membrane receptor, enzyme, transporter, or transcription factor. No drugs, biomarkers, or safety considerations have been reported for this transcript[5][7]. Key distinction: COL25A1-DT should not be confused with COL25A1 (collagen type XXV alpha 1 chain), which is a protein-coding gene implicated in neurobiology and Alzheimer’s disease[1][2][4][6]. COL25A1-DT’s annotation as "ZCCHC23" likely represents predicted homology rather than established protein function, and there is no literature supporting its classification as a therapeutic target or receptor. Summary: COL25A1 divergent transcript is a putative noncoding RNA gene with limited characterization and no established therapeutic, biological, or disease relevance. It is not a canonical molecular target. Data are insufficient for inclusion as a drug target, biomarker, or safety concern.
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