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Target intelligence / Profile preview
Cold-sensitive transient receptor potential cation channel subfamily M member 8 (TRPM8)
- Target
- TRPM8
- Molecular classification
- Ion channel, Transient Receptor Potential (TRP) channel, Cation channel
01
Overview
TRPM8 is a non-selective, voltage-dependent cation channel that functions as the primary molecular transducer of cold somatosensation. Activated by cool temperatures and chemical agonists like menthol, it mediates the influx of cations into sensory neurons, resulting in the sensation of cold. It is implicated in neuropathic pain, cancer, and other diseases.
- Other names
- Cold and menthol receptor 1CMR1
02
Mechanism of action
Activation of TRPM8 leads to influx of cations, particularly calcium, into sensory neurons, triggering cold sensation.
03
Biological functions
SomatosensationThermosensationCalcium signalingDetection of environmental cold
04
Disease associations
Neuropathic painCancerPain syndromes involving abnormal cold sensitivity
05
Safety considerations
Achieving specificity without off-target effectsChallenges in developing potent clinical modulators
06
Interacting drugs
Menthol
2 more in the full profile.
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