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Target intelligence / Profile preview
Coli Surface Antigen 3 (CS3)
- Target
- CS3
- Molecular classification
- Fibrillar protein, Colonization Factor Antigen
01
Overview
CS3 is a fibrillar colonization factor expressed on the surface of enterotoxigenic Escherichia coli (ETEC). It mediates adhesion to human intestinal epithelial cells, facilitating colonization and subsequent toxin delivery that leads to diarrheal disease. It is a key target for vaccine development against ETEC.
- Other names
- CFA/II (with CS3)Colonization Factor CS3
02
Biological functions
AdhesionColonizationReceptor binding
03
Disease associations
InfectionDiarrheal diseaseEnterotoxigenic Escherichia coli infection
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