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Target intelligence / Profile preview
Colitis associated IRF1 antisense regulator of intestinal homeostasis (CARINH)
- Target
- CARINH
- Molecular classification
- Long non-coding RNA, Non-coding RNA
01
Overview
Colitis associated IRF1 antisense regulator of intestinal homeostasis (CARINH) is a long non-coding RNA located adjacent to the IRF1 gene. CARINH is essential for maintaining gut immune homeostasis and protecting against colitis by forming a feedforward regulatory loop with IRF1 in myeloid cells. This loop, activated by microbial factors, regulates anti-inflammatory and antimicrobial programs in the intestine. Genetic variants affecting CARINH expression modulate susceptibility to inflammatory bowel disease. CARINH is not a protein, enzyme, receptor, or transporter, and currently has no direct therapeutic agents or clinical interventions targeting it
- Other names
- C5orf56IRF1-AS1
02
Biological functions
Regulation of transcription (via IRF1 regulation)Maintenance of intestinal immune homeostasisControl of intestinal inflammationModulation of host-microbiota interaction
03
Disease associations
Inflammatory bowel disease (IBD)Colitis
04
Biomarkers
rs2188962 risk allele
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