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Target intelligence / Profile preview
Collagen alpha-1(III) chain (COL3A1)
- Target
- COL3A1
- Molecular classification
- Fibrillar Collagen, Extracellular Matrix Protein
01
Overview
Collagen type III is a fibrillar collagen and a major structural protein in the extracellular matrix of various tissues, particularly in extensible connective tissues like blood vessels, uterus, bowel, and skin. It provides tensile strength and structural support, regulates type I collagen fibril diameter, and plays a role in wound healing and hemostasis. Mutations in the COL3A1 gene, which encodes the alpha-1(III) chain of collagen type III, cause vascular Ehlers-Danlos syndrome (vEDS), a life-threatening condition characterized by fragile blood vessels prone to rupture.
- Other names
- Collagen, type III, alpha 1Alpha-1 type III collagenEhlers-Danlos syndrome, vascular type
02
Mechanism of action
N/A
03
Biological functions
Tensile strengthRegulation of type I collagen fibril diameterWound healingHemostasisStructural support
04
Disease associations
Vascular Ehlers-Danlos syndrome (vEDS)FibrosisConnective Tissue Disorders
05
Safety considerations
Fragile blood vesselsRisk of arterial ruptureRisk of intestinal rupture
06
Biomarkers
COL3A1 mutations (diagnosis of vEDS)Collagen type III levels (assessment of fibrosis)
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