Collagen-like tail subunit of asymmetric acetylcholinesterase (COLQ)

Collagen-like tail subunit of asymmetric acetylcholinesterase (COLQ) is a structural protein essential for anchoring acetylcholinesterase (AChE) to the basal lamina at the neuromuscular junction[1][2][4]. COLQ forms a homotrimer, with each subunit containing a proline-rich attachment domain (PRAD) that binds and anchors acetylcholinesterase tetramers[1][4]. This positioning is critical for efficient hydrolysis of acetylcholine, terminating synaptic transmission and ensuring proper muscle contraction[2][3]. Mutations in the COLQ gene lead to a reduction or absence of synaptic AChE, resulting in congenital myasthenic syndrome characterized by muscle weakness and impaired neuromuscular signaling[2][3][4]. COLQ is also required for the assembly and accumulation of some forms of butyrylcholinesterase at neuromuscular junctions[3].

Other names

Acetylcholinesterase collagenic tail peptideAChE Q subunitAcetylcholinesterase-associated collagenCollagenic tail of endplate acetylcholinesteraseSingle strand of homotrimeric collagen-like tail subunit of asymmetric acetylcholinesteraseCollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesteraseCMS5EAD