Collagen Production in Fibroblasts

Collagen production in fibroblasts refers to the cellular process by which fibroblast cells synthesize and secrete collagen, a primary structural protein of the extracellular matrix (ECM). This process is essential for tissue integrity, wound healing, and repair. It involves gene transcription, translation, post-translational modification, transport, and secretion of collagen molecules that self-assemble into fibrils and fibers. The process is regulated by growth factors (TGF-β, bFGF, γ-IFN), mechanical tension, and the metabolic state of the fibroblasts. Dysregulation of collagen production contributes to pathological conditions like fibrosis and impaired wound healing.

Other names

Fibroblast Collagen SynthesisECM Deposition by Fibroblasts