Target intelligence / Profile preview

Collagen Type I

Molecular classification: Extracellular matrix protein, Structural protein

Overview

Collagen type I is the most abundant collagen in the human body, providing strength and structure to various tissues including skin, bone, tendons, and ligaments. It is a fibril-forming collagen consisting of two α1(I) chains and one α2(I) chain, encoded by the COL1A1 and COL1A2 genes, respectively. Mutations in these genes can lead to disorders such as osteogenesis imperfecta and Ehlers-Danlos syndrome. Type I collagen is extensively used as a biomaterial in tissue engineering and wound healing applications.

Mechanism of action

N/A

Biological functions

Structural supportTensile strengthCell-matrix interactionTissue developmentWound healing

Disease associations

Osteogenesis imperfectaEhlers-Danlos syndromeSclerodermaRheumatoid arthritis

Safety considerations

Age-related decline in synthesis and qualityPotential for autoimmune reactions

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