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Collagen Type II peptide antigen presentation via MHC Class II on dendritic cells
- Molecular classification
- Antigen presentation pathway, MHC Class II pathway
01
Overview
Collagen type II is a fibrillar protein found in cartilage. Dendritic cells process collagen type II peptides and present them via MHC class II molecules, leading to CD4+ T cell activation and potential autoimmune responses. This process is central to the development of autoimmune arthritis, such as collagen-induced arthritis (CIA).
02
Biological functions
Antigen processingAntigen presentationT cell activationImmune response
03
Disease associations
Autoimmune arthritisCollagen-induced arthritisRheumatoid arthritis
04
Safety considerations
Potential for off-target effects on other immune pathwaysRisk of immunosuppression if antigen presentation is broadly inhibited
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