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Target intelligence / Profile preview
Collagen type VI alpha 5 chain (COL6A5)
- Target
- COL6A5
- Molecular classification
- Collagen superfamily, Extracellular matrix protein, von Willebrand factor A domain-containing protein
01
Overview
Collagen type VI alpha 5 chain (COL6A5) is a large extracellular matrix glycoprotein involved in the supramolecular assembly of collagen VI microfilaments, which provide mechanical strength and cytoprotective functions to multiple tissues, including muscle, skin, lung, testis, colon, and small intestine. The COL6A5 gene encodes a protein with multiple von Willebrand factor A-like domains, facilitating interactions with other matrix components and helping organize tissue architecture. Mutations and altered expression are linked to diseases such as muscular dystrophy and eczema. COL6A5 is primarily a structural and regulatory ECM molecule and is not currently regarded as a direct drug target or biomarker in clinical pharmacology.
- Other names
- Collagen alpha-5(VI) chainCOL6A5COL29A1VWA4Collagen alpha-1(XXIX) chainvon Willebrand factor A domain-containing protein 4von Willebrand factor A domain containing 4FLJ35880
02
Biological functions
Extracellular matrix organizationMechanical support of tissuesCell adhesion/cell bindingCytoprotection (including anti-apoptotic effects and resistance to oxidative damage)Regulation of cell differentiation and autophagyMaintenance of cell stemness
03
Disease associations
Muscular dystrophies (e.g., Ullrich congenital muscular dystrophy)DermatitisEczemaTissue homeostasis disorders
04
Safety considerations
Genetic polymorphisms and mutations may predispose to muscular dystrophies and certain skin disorders (e.g., dermatitis)No safety concerns noted for therapeutics—because it is not targeted by drugs.
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