Collagen type XIV alpha 1 chain (COL14A1)

Collagen type XIV alpha 1 chain (COL14A1) is a structural protein encoded by the COL14A1 gene and belongs to the FACIT (fibril-associated collagens with interrupted triple helices) collagen family[1][4][2]. It plays a key regulatory role in the assembly, organization, and biomechanics of the extracellular matrix by binding to collagen fibrils and supporting proper fibril formation and tissue strength, especially in connective tissues such as tendons, skin, cornea, and lung[1][7][4]. COL14A1 interacts with other matrix molecules and is involved in cell adhesion, regulating cell proliferation and differentiation in various tissues. Altered expression or mutations in this gene have been implicated in fibrotic diseases, some cutaneous disorders, and potentially serve as biomarkers in specific cancer classifications and fibrotic conditions[1][4][7]. COL14A1 is not presently considered a classical therapeutic target such as a receptor, enzyme, or transporter; instead, it functions primarily as an extracellular matrix structural regulator[1][2].

Other names

Collagen alpha-1(XIV) chainCOL14A1UNDUndulincollagen, type XIV, alpha 1undulin (fibronectin-tenascin-related)