Collagen type XV alpha 1 chain (COL15A1)

Collagen type XV alpha 1 chain (COL15A1) encodes a non-fibrillar collagen of the multiplexin subfamily, characterized by a collagenous region interrupted by non-collagenous domains and a proteoglycan-modified N-terminal segment[1][2][3][5]. This protein predominantly localizes to basement membranes, where it maintains tissue architecture by anchoring membranes to underlying stroma[1][2][5]. The C-terminal region, known as restin, can be proteolytically released and has demonstrated anti-angiogenic activity similar to endostatin[1][2][5]. COL15A1 is essential for vascular and muscle stability, and its deficiency in mice leads to microvessel and muscle deterioration, altered tissue stiffness, and increased inflammation[1][2]. Additionally, changes in COL15A1 expression affect tissue remodeling and repair, and dysregulation has been implicated in pathological states such as cancer, cardiovascular disease, and neuromuscular disorders[1][2][5]. COL15A1 is not a conventional drug target such as a receptor, enzyme, or transporter, but alterations in its function or expression may contribute to disease pathogenesis. **Note:** - COL15A1 is primarily a structural extracellular matrix protein, not a receptor, enzyme, or typical "therapeutic target," though its role in tumor suppression and anti-angiogenesis is under active investigation[1][2][3][5]. - No clinically approved drugs are known to directly interact with COL15A1 or its fragments as pharmacological targets. It is mainly studied for its structural and potential tumor-suppressive properties[2][3][5].

Other names

Collagen alpha-1(XV) chainCollagen XVRestinEndostatin-XVCollagen XV proteoglycancollagen, type XV, alpha 1Restin-IRestin-IIRestin-IIIRestin-IV