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Target intelligence / Profile preview
Collagen type XVI alpha 1 chain (COL16A1)
- Target
- COL16A1
- Molecular classification
- Fibril-associated collagen with interrupted helices (FACIT family), Extracellular matrix protein
01
Overview
Collagen type XVI alpha 1 chain is an extracellular matrix protein and member of the FACIT collagen family. These proteins associate with fibril-forming collagens and contribute to the integrity and organization of the extracellular matrix, especially in tissues such as skin, cartilage, fibroblasts, keratinocytes, smooth muscle, and amnion[1][5]. Collagen XVI mediates integrin-based cell adhesion, participates in cell spreading and shape changes, and is involved in assembly of focal adhesions[5][6][9]. It forms homotrimers and interacts with structural proteins like fibrillin-1 and fibronectin, integrating into specialized microfibrils and cartilage fibrils[3]. The NC11 domain may serve as a biomarker in oral squamous cell carcinoma, but the protein itself is not a known drug target or common receptor, enzyme, or transporter implicated in direct therapeutic strategies[7].
- Other names
- Collagen alpha-1(XVI) chainCOL16A1Alpha 1 type XVI collagen447AAFP1572Collagen XVIAlpha-1 polypeptideCollagen, type XVI, alpha 1
02
Biological functions
Maintenance of extracellular matrix integrityMediating cell attachmentInducing integrin-mediated cellular reactions (cell spreading, cell morphology changes)Cell adhesion mediated by integrinAssociation with fibril-forming collagens (type I and II)Positive regulation of focal adhesion assembly
03
Disease associations
Synovium neoplasmBiomarker for oral squamous cell carcinoma (NC11 domain)
04
Biomarkers
NC11 domain of collagen XVI is a potential biomarker for oral squamous cell carcinoma
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