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Target intelligence / Profile preview
Collagen type XX alpha 1 chain (COL20A1)
- Target
- COL20A1
- Molecular classification
- Other (fibrillar collagen family, extracellular matrix protein)
01
Overview
Collagen type XX alpha 1 chain (COL20A1) is a protein encoded by the COL20A1 gene in humans and is part of the collagen superfamily, a large group of extracellular matrix proteins that provide structural support to connective tissues. Type XX collagen is one of the lesser-characterized collagen types, and functional information remains limited. Initial studies suggest it may play roles in the formation and maintenance of specific connective tissues. Rare genetic variants in COL20A1 have been proposed as candidates associated with striate palmoplantar keratoderma (PPKS), expanding the spectrum of genetic contributors to this disorder. Detailed molecular roles, disease associations, and potential as a therapeutic target have not been established in the current literature[4][6].
- Other names
- Collagen alpha-1(XX) chainKIAA1510collagen, type XX, alpha 1collagen-like protein
02
Biological functions
Extracellular matrix structural supporttissue morphogenesiscell adhesion (*inferred based on family and limited source data*)
03
Disease associations
Other (implicated in striate palmoplantar keratoderma (PPKS); broader disease relevance largely unknown)
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