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Target intelligence / Profile preview
Collagen type XXVIII alpha 1 chain (COL28A1)
- Target
- COL28A1
- Molecular classification
- Collagen superfamily, Extracellular matrix protein, Structural protein, Other
01
Overview
Collagen type XXVIII alpha 1 chain (COL28A1) is a member of the collagen superfamily and encodes a structural component of the extracellular matrix, characterized by von Willebrand factor type A domains[1][2][5][3]. It is primarily thought to serve as a cell-binding protein and may play a role in collagen trimerization and tissue organization[4][5][6][3]. The COL28A1 gene is located on chromosome 7 and is expressed in various tissues. While some associations with diseases such as cerebellar ataxia type 9 have been reported, there is limited information on direct therapeutic targeting or clinical applications[3][8]. It is not currently recognized as a major receptor, enzyme, or drug target.
- Other names
- Collagen alpha-1(XXVIII) chainCOL28A1Collagen type XXVIII alpha 1COL28Collagen, type XXVIII, alpha 1
02
Biological functions
Structural component of extracellular matrixMay act as a cell-binding protein[4][5][9][6]Involvement in collagen trimerization and extracellular matrix organization[3]
03
Disease associations
Other (reported association with Cerebellar ataxia type 9, Epididymis disease)[3]Potential mechanistic role in proliferation, migration, and epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells (preclinical/functional data, not clinical biomarker)[8]
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