Target intelligence / Profile preview

Collagenase

Molecular classification: Enzyme, Metalloproteinase, Peptidase

Overview

Collagenases are a family of enzymes that catalyze the breakdown of collagen, a major structural protein in the extracellular matrix. They are involved in both physiological processes like tissue remodeling and pathological conditions as virulence factors. Examples include bacterial collagenases (e.g., from *Clostridium histolyticum*) and mammalian collagenases (e.g., MMP1, MMP8).

Mechanism of action

Hydrolyzes peptide bonds in collagen

Biological functions

Extracellular matrix remodelingTissue degradationWound healingImmune responseVirulence factor (bacterial)

Disease associations

Fibrotic disordersWound healing complicationsInfectionCancer (related to ECM remodeling)

Safety considerations

Allergic reactionsInjection site reactionsTendon ruptureNerve damageSkin discoloration

Interacting drugs

Xiaflex

4 more in the full profile.

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