Target intelligence / Profile preview

Collagenase

Molecular classification: Enzyme, Metalloproteinase, Peptidase

Overview

Collagenases are a family of enzymes that catalyze the breakdown of collagen, a major structural protein in the extracellular matrix. They are involved in both physiological processes like tissue remodeling and pathological conditions as virulence factors. Examples include bacterial collagenases (e.g., from *Clostridium histolyticum*) and mammalian collagenases (e.g., MMP1, MMP8).

Mechanism of action

Hydrolyzes peptide bonds in collagen

Biological functions

Extracellular matrix remodelingTissue degradationWound healingImmune responseVirulence factor (bacterial)

Disease associations

Fibrotic disordersWound healing complicationsInfectionCancer (related to ECM remodeling)

Safety considerations

Allergic reactionsInjection site reactionsTendon ruptureNerve damageSkin discoloration

Interacting drugs

Xiaflex

4 more in the full profile.

Beyond the preview

Go deeper on Collagenase.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Collagenase.

Explore the full profile