Collapsin response mediator protein 1 (CRMP1)

Collapsin response mediator protein 1 (CRMP1) is a cytosolic phosphoprotein predominantly expressed in the nervous system, where it regulates critical developmental processes including axon guidance, dendritic development, and synaptic maturation by mediating semaphorin and reelin signaling pathways. CRMP1 functions downstream of class 3 semaphorins (e.g., SEMA3A) to remodel the neuronal cytoskeleton through direct interactions with microtubules and actin filaments, facilitating growth cone collapse and neural circuit formation. CRMP1 forms tetramers and interacts with other CRMP family members, and its activity is regulated by phosphorylation through kinases such as Cdk5, GSK-3β, and Fyn, which impacts neuronal migration, plasticity, and possibly cytokinesis. Disruption or mutation of CRMP1 is implicated in neurodevelopmental diseases, cognitive dysfunction, and has a role in certain cancers. Key references for the functions, structure, and disease linkage include several structural biology, neurodevelopmental genetics, and general summaries from genetic databases. There are currently no known drugs or established biomarkers for CRMP1, and direct targeting as a therapeutic is not reported, but it remains a significant node in neural signal transduction and development.

Other names

Dihydropyrimidinase-related protein 1DPYSL1ULIP3DRP-1CRMP-1ULIP-3DRP1Unc-33-like phosphoprotein 3inactive dihydropyrimidinase