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Target intelligence / Profile preview
Collapsin Response Mediator Protein 2 (CRMP2)
- Target
- CRMP2
- Molecular classification
- Cytoskeletal protein, Phosphoprotein
01
Overview
CRMP2 is a cytosolic phosphoprotein crucial for neuronal development, particularly axon guidance, neuronal polarity, microtubule dynamics, and synaptic plasticity. Its function is tightly regulated by phosphorylation, and hyperphosphorylation has been implicated in Alzheimer's disease pathogenesis. It interacts with tubulin, promoting microtubule assembly and stability. Targeting CRMP2's protein-protein interactions may offer therapeutic avenues for diseases characterized by abnormal neural connectivity or degeneration.
02
Biological functions
Neuronal polarity establishmentMicrotubule assembly/dynamicsAxon guidanceSynapse maturationDendritic branchingTarget recognition during neural circuit formation
03
Disease associations
Neurodegenerative diseaseAlzheimer's Disease
04
Safety considerations
Aberrant regulation/phosphorylation may contribute to neurodegenerative processes
05
Biomarkers
Hyperphosphorylated CRMP2 (Alzheimer's Disease)
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