Target intelligence / Profile preview

Collateral air channel of the lung

Molecular classification
Other
01

Overview

Collateral air channels of the lung describe anatomical pathways that allow for airflow between different lung compartments (such as between adjacent alveoli via pores of Kohn, between bronchioles and alveoli via canals of Lambert, and between bronchioles via channels of Martin), especially when the primary airways are obstructed. These channels help maintain some degree of ventilation and can prevent complete collapse (atelectasis) of lung tissue in the setting of proximal airway occlusion. While not significant under normal conditions, they are clinically relevant in disease states like emphysema, where airflow obstruction is common and collateral ventilation can significantly impact the outcome of treatments such as lung volume reduction surgery or endobronchial valve placement[1][2][3][4].

Other names
Collateral ventilation pathwaysCollateral channelsPores of KohnCanals of LambertChannels of Martin
02

Mechanism of action

None (not applicable for drugs; device-based procedures like endobronchial valves are affected by their presence)

03

Biological functions

Alternative airflow pathwaysMaintenance of ventilation during proximal airway obstruction
04

Disease associations

Other (most relevant in lung diseases such as emphysema, asthma, bronchial obstruction, bronchiolitis obliterans)
05

Safety considerations

May hinder efficacy of lung volume reduction therapies (e.g., endobronchial valve procedures); can complicate surgical or interventional management of emphysema and other lung diseases

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