Collectin liver 1 (CL-L1)

Collectin liver 1 (CL-L1, encoded by the COLEC10 gene) is a **soluble pattern recognition protein** of the collectin family, specifically a **C-type lectin** that contains collagen-like sequences and carbohydrate recognition domains[6][8]. CL-L1 plays a key role in the **lectin complement pathway**, contributing to the recognition and removal of pathogens and regulation of cell migration during embryonic development—especially of neural crest cells, with implications for facial, cranial, and other tissue morphogenesis[1][3][8]. Mutations in COLEC10 cause **3MC syndrome**, a disorder with diverse developmental defects[1][3][8]. Recent research suggests that CL-L1 also has **tumor suppressor functions** in hepatocellular carcinoma by inhibiting cell proliferation, migration, and EMT, likely via PI3K-AKT, Hedgehog, and p53 signaling pathways[2]. While it is essential for several physiological processes, CL-L1 is not considered a classical drug target (such as a receptor or enzyme), but may serve as a **prognostic biomarker for cancer** and a molecular marker of certain rare genetic syndromes[2][8].

Other names

Collectin-10COLEC10CLL1UNQ366/PRO702CL-L1CL-34Collectin-34collectin liver 1collectin liver protein 1collectin sub-family member 10 (C-type lectin)3MC3collectin-10