Molecular Classification
Anatomical Space, Gastrointestinal Compartment
Disease Roles
Inflammatory bowel disease (IBD)Colorectal cancerInfectious diseases (e.g., Clostridium difficile infection)

Colon Lumen Overview

The colon lumen is the interior space within the colon, responsible for the final stages of digestion, including water and electrolyte absorption, feces formation, and hosting a diverse gut microbiota. It is a critical interface between the host tissue and the gut microbiome, influencing overall health and susceptibility to various gastrointestinal diseases.

Mechanism of Action

Biological Functions

Water and electrolyte absorption
Feces formation and propulsion
Microbial fermentation
Nutrient absorption
Vitamin synthesis

Disease Associations

Inflammatory bowel disease (IBD)
Colorectal cancer
Infectious diseases (e.g., Clostridium difficile infection)
Malabsorption
Constipation
Diarrhea

Safety Considerations

  • Risk of infection
  • Electrolyte imbalance
  • Dehydration
  • Adverse drug reactions
  • Intestinal perforation
  • Toxic megacolon

Interacting Drugs

Laxatives
Anti-diarrheal medications
Antibiotics
Anti-inflammatory drugs (e.g., corticosteroids, aminosalicylates)

Associated Biomarkers

Biomarker
Fecal calprotectin (inflammation)
Fecal occult blood test (FOBT) (bleeding)
CEA (Carcinoembryonic antigen, colorectal cancer)
Fecal microbiota composition (dysbiosis)