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Large Intestine Smooth Muscle
- Molecular classification
- Smooth Muscle, Muscle Tissue
01
Overview
Large intestine smooth muscle refers to the layers of involuntary, non-striated muscle found in the wall of the large intestine. These muscles are responsible for generating contractions that propel and mix intestinal contents, facilitating water absorption, vitamin production/absorption, and feces formation and propulsion. Its function is regulated by the enteric nervous system, autonomic nervous system, and hormonal signals.
- Other names
- Colon Smooth MuscleLarge Bowel Smooth Muscle
02
Mechanism of action
Contraction or relaxation of smooth muscle cells mediated by various receptors and neurotransmitters.
03
Biological functions
PeristalsisSegmentationMixing of intestinal contentsWater and electrolyte absorptionFeces formationFeces propulsionMaintenance of organ shape
04
Disease associations
ConstipationIrritable Bowel Syndrome (IBS)Colonic InertiaSpastic Colon
05
Safety considerations
Dysregulation can lead to motility disorders.Drug interactions affecting smooth muscle function.
06
Interacting drugs
Acetylcholine
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