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Target intelligence / Profile preview
Colon Epithelial Cell
- Molecular classification
- Cell, Epithelial Cell
01
Overview
Colon epithelial cells are the primary cell type lining the luminal surface of the colon. They form a single layer of columnar epithelial cells, which are organized into crypts and play essential roles in nutrient absorption, barrier function, immune modulation, and maintenance of intestinal homeostasis. The colonic epithelium comprises several specialized cell types, including enterocytes, goblet cells, and enteroendocrine cells, all derived from stem cells at the base of the crypts.
- Other names
- ColonocyteIntestinal Epithelial Cell (IEC)Colonic Epithelium
02
Biological functions
AbsorptionBarrier FunctionImmune ModulationSecretionHomeostasisRegeneration
03
Disease associations
Colorectal CancerInflammatory Bowel Disease (IBD)InfectionOther Gastrointestinal Diseases
04
Safety considerations
Dysregulation can lead to cancerBarrier disruption can lead to inflammation and infection
05
Biomarkers
CD44LGR5EpCAM
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