Colonic proteins

Colonic proteins refers to the diverse ensemble of proteins expressed within the tissues of the large intestine, collectively known as the colonic proteome [1, 5, 15]. This broad category encompasses various molecular classes, including structural proteins like Mucin-2 that maintain the mucosal barrier, transport proteins for electrolyte balance, and signaling molecules involved in local immune regulation [6, 17]. Because it includes thousands of distinct gene products, 'Colonic proteins' is not considered a single therapeutic target; instead, specific members of this group are targeted for treating inflammatory bowel disease (IBD) and colorectal cancer [1, 2, 4]. In experimental pharmacology, this term is frequently used in the context of the TNBS-induced colitis model, where the chemical agent haptens native colonic proteins, rendering them immunogenic and triggering a T cell-mediated inflammatory response [7, 12, 18]. Furthermore, the colon's relatively low proteolytic activity compared to the small intestine makes it a significant site for the targeted delivery of therapeutic protein and peptide drugs [19, 20].

Other names

Proteins of the large intestineColonic proteomeLarge intestinal proteins

Haptenation of native proteins in experimental models of colitis