Colonic smooth muscle cell

Colonic muscles refers to the layers of smooth muscle that comprise the muscularis propria and muscularis mucosae of the colon wall[3][5][9]. These cells are responsible for generating the coordinated contractions (peristalsis and segmental mixing) that propel and mix the colonic contents. Colonic smooth muscle is regulated by the enteric nervous system, hormones, and various receptors (such as muscarinic acetylcholine receptors, ion channels including L-type Ca²⁺ channels, and potassium channels)[2][4][10]. Smooth muscle contraction in the colon is dependent on increased intracellular calcium, calmodulin activation, and myosin light chain kinase (MLCK) activity, leading to phosphorylation of myosin and subsequent cross-bridge cycling with actin for force generation[1][9]. Dysfunction of colonic smooth muscle or its regulation can result in diseases such as colonic pseudo-obstruction or motility disorders. Individual proteins expressed in these cells (e.g., specific receptors or ion channels) are the actual molecular targets in therapy and pharmacology. Summary: "Colonic muscles" designates a tissue or cell type, not a molecular target or receptor. For structured pharmacological or molecular targeting purposes, individual receptors or ion channels within these muscles (e.g., muscarinic acetylcholine receptors, L-type calcium channels, potassium channels) are the relevant entities[2][4][10]. The entry is therefore considered incorrect as a therapeutic "target" per standard conventions.

Other names

Colonic musclesColonic smooth muscleColon muscularisIntestinal smooth muscle (colon)