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Target intelligence / Profile preview
Colonization Factor Antigen II Fimbriae (CFA/II)
- Target
- CFA/II
- Molecular classification
- Bacterial adhesin, Fimbria, Class 5 fimbriae
01
Overview
Colonization factor antigen II (CFA/II) fimbriae are surface-exposed, proteinaceous appendages produced by certain strains of enterotoxigenic Escherichia coli (ETEC). These fimbriae mediate bacterial adhesion to host intestinal epithelial cells, essential for colonization and diarrheal disease. Consisting of polymerized major subunits and minor adhesive tip subunits, they are highly immunogenic and serve as a target for anti-adhesion therapies and vaccine development, particularly focusing on the minor adhesive subunits.
- Other names
- CFA/II fimbriaeColonization factor antigen IIETEC adhesin CFA/II
02
Mechanism of action
Anti-fimbrial antibodies can inhibit adhesion by compromising the mechanical resilience of the fimbriae, preventing proper host cell attachment.
03
Biological functions
Bacterial adhesionColonizationHost cell binding
04
Disease associations
InfectionDiarrheal diseaseEnterotoxigenic Escherichia coli (ETEC) infection
05
Safety considerations
Potential for off-target effects if antibodies cross-react with other host structures.Development of resistance through antigenic variation.
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