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Target intelligence / Profile preview
Colonization Surface Antigen 2 (CS2)
- Target
- CS2
- Molecular classification
- Fimbrial protein, Adhesin
01
Overview
CS2 antigen is a fimbrial protein found on the surface of certain strains of enterotoxigenic E. coli (ETEC). It mediates adhesion between ETEC and human jejunal epithelial cells, facilitating bacterial colonization and subsequent infection.
- Other names
- CFA/II CS2CS2 fimbriaeCS2 pilus
02
Mechanism of action
Monoclonal antibodies can block adhesion and neutralize the bacteria.
03
Biological functions
Adhesion to intestinal epitheliumColonization factor
04
Disease associations
Enterotoxigenic E. coli infectionDiarrheal disease
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