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Target intelligence / Profile preview
Colony stimulating factor 2 receptor subunit beta (CSF2RB)
- Target
- CSF2RB
- Molecular classification
- Receptor, Cytokine Receptor, Type I cytokine receptor
01
Overview
Colony stimulating factor 2 receptor subunit beta (CSF2RB) is a shared signaling component for receptors of GM-CSF, IL-3, and IL-5. Upon ligand binding, CSF2RB mediates signal transduction via JAK/STAT, MAPK/ERK, and PI3K/Akt pathways, regulating proliferation, differentiation, and survival in hematopoietic cells. Dysregulation or mutation of CSF2RB can lead to immune-related disorders.
- Other names
- CD131CDw131IL3RBIL5RBSMDP5Colony stimulating factor 2 receptor beta common subunitbetaGMR
02
Mechanism of action
JAK/STAT pathway activation; MAPK/ERK pathway activation; PI3K/Akt pathway activation
03
Biological functions
Signal transductionCell proliferationCell differentiationSurvival/apoptosis preventionImmune response
04
Disease associations
Surfactant metabolism dysfunction type 4Immune-related disordersCancer
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