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Target intelligence / Profile preview
Colony Stimulating Factor 3 Receptor (CSF3R)
- Target
- CSF3R
- Molecular classification
- Receptor, Transmembrane protein
01
Overview
Colony stimulating factor 3 receptor (CSF3R), also known as granulocyte colony-stimulating factor receptor (G-CSF-R) or CD114, is a cell-surface transmembrane protein that serves as the receptor for granulocyte colony-stimulating factor (G-CSF/CSF3). This cytokine-receptor interaction is essential for the regulation of production, differentiation, and function of neutrophilic granulocytes in the bone marrow. Mutations in CSF3R are implicated in several hematologic disorders, including chronic neutrophilic leukemia. Recombinant G-CSFs like filgrastim act through this receptor for therapeutic stimulation of white blood cell counts. Targeted therapies against aberrant CSF3R signaling—such as JAK inhibitors—are under investigation for malignancies driven by activating mutations.
- Other names
- G-CSF-RGCSFRCD114SCN7Granulocyte colony-stimulating factor receptor
02
Mechanism of action
Agonist (G-CSF analogs); Inhibition of downstream signaling pathways (JAK inhibitors)
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalImmune responseRegulation of granulocyte production
04
Disease associations
Chronic Neutrophilic LeukemiaAtypical chronic myeloid leukemiaAcute myeloid leukemiaChronic myelomonocytic leukemiaSevere congenital neutropeniaMyelodysplastic syndromePhiladelphia chromosome-positive acute lymphoblastic leukemia
05
Safety considerations
Potential for cytokine storm with G-CSF analogsOff-target effects of JAK inhibitors
06
Interacting drugs
Filgrastim
1 more in the full profile.
07
Biomarkers
CSF3R mutations (e.g., T618I, M696T) for diagnosis and prognosisNeutrophil count
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