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Target intelligence / Profile preview
Colony Stimulating Factor Receptor Type 1 (CSF1R)
- Target
- CSF1R
- Molecular classification
- Receptor, Type III protein tyrosine kinase receptor
01
Overview
The colony stimulating factor receptor type 1, encoded by CSF1R, is essential for normal development, function, and survival across multiple tissue-resident immune populations. Its dysregulation contributes directly to pathologies ranging from neurodegeneration to cancer. It is a receptor tyrosine kinase activated by CSF-1/M-CSF and IL-34, primarily expressed on myeloid lineage cells.
- Other names
- Macrophage colony-stimulating factor receptorM-CSFRCD115c-FMS
02
Mechanism of action
CSF1R inhibitors block the tyrosine kinase activity of the receptor, preventing downstream signaling. Antibodies against CSF1/M-CSF neutralize the ligand, preventing receptor activation.
03
Biological functions
Signal transductionCell survivalCell proliferationCell differentiationMyelopoiesis regulationImmune response modulationOsteoclastogenesisCentral nervous system maintenance
04
Disease associations
CancerInflammationNeurodegenerative diseaseAdult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)Systemic lupus erythematosusArthritisAtherosclerosisObesity
05
Safety considerations
Generally favorable safety profiles observed in clinical trials of CSF1R inhibitors so far.
06
Interacting drugs
CSF1R inhibitors
2 more in the full profile.
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