Combined viral–immune–enzymatic network

The Combined viral–immune–enzymatic network is a systems biology framework, notably described in research regarding COVID-19 (Sahoo et al., 2021, Processes), that integrates viral kinetics, host immune responses, and enzymatic pathways. This model maps the interactions between SARS-CoV-2, the innate and adaptive immune systems, and the Renin-Angiotensin System (RAS), specifically focusing on the role of the ACE2 enzyme as both a viral entry point and a regulator of inflammation. By simulating these interconnected processes, the network helps identify how viral load and immune signaling contribute to disease states like cytokine storms and respiratory distress. While it provides a comprehensive view of disease pathology, it is a conceptual and mathematical model rather than a single molecular target. Therefore, it is used for predicting therapeutic outcomes and understanding systemic interactions rather than being a direct site for drug binding.

Other names

Viral-immune-enzymatic network modelCOVID-19 systems biology network