Combretastatin A4 phosphate (CA4P)

Combretastatin A4 phosphate is a water-soluble prodrug of combretastatin A-4, a natural stilbene derivative originally isolated from the African bushwillow tree (*Combretum afrum*). As a microtubule inhibitor, it acts by binding to the colchicine site of tubulin, halting mitosis and resulting in rapid disruption of the tumor vasculature. Its effectiveness in inducing central necrosis of tumors makes it a promising candidate for anti-cancer therapy, commonly used as a vascular disrupting agent especially in combination with chemotherapy. CA4P is delivered as a phosphate salt to improve solubility and is converted to the active form (combretastatin A-4) in the body

Other names

FosbretabulinCombretastatin A-4 phosphateCA4PCA4PDfosbretabulin disodiumfosbretabulin tromethamineCRC 8709

Prodrug rapidly converted to combretastatin A-4 in vivo; CA-4 binds to the colchicine site on tubulin, inhibits tubulin polymerization, destabilizes microtubules, disrupts tumor vasculature, and induces tumor necrosis