Molecular Classification
Receptor, Cytokine Receptor, Type I cytokine receptor
Other Names
Cytokine Receptor Common Subunit Gamma, Interleukin-2 Receptor Subunit Gamma, IL-2RG, γc
Disease Roles
X-linked severe combined immunodeficiency disease (X-SCID)ImmunodeficiencyAutoimmune diseases

Common Gamma Chain Receptor Subunit Overview

The common gamma chain receptor subunit is a critical component of several interleukin receptors, acting as a shared signaling subunit for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. It is essential for lymphocyte development and function, particularly T cell, B cell, and NK cell maturation. Mutations in the IL2RG gene result in X-linked severe combined immunodeficiency (X-SCID).

Mechanism of Action

Modulation of cytokine signaling through receptor complex formation and downstream JAK/STAT pathway activation.

Biological Functions

Signal transduction
Immune response
Lymphocyte development
T cell activation
B cell function
NK cell development

Disease Associations

X-linked severe combined immunodeficiency disease (X-SCID)
Immunodeficiency
Autoimmune diseases

Safety Considerations

  • Potential for exacerbating autoimmune diseases via soluble forms.
  • Therapeutic targeting must consider pleiotropic effects due to involvement in multiple cytokine signaling pathways.