Complement 5a Receptor (C5aR)

Complement 5a Receptor (C5aR), also known as CD88 or C5AR1, is a G protein-coupled receptor that binds the complement component C5a. It is widely expressed on immune cells and mediates many of the pro-inflammatory effects of C5a, including chemotaxis, cytokine secretion, and phagocytosis. C5aR activation leads to downstream signaling through Gαi proteins, ERK1/2 phosphorylation, calcium mobilization, and Rho activation. Because excessive complement activation contributes to various diseases, C5aR is an attractive drug target for anti-inflammatory therapies, particularly for autoimmune disorders and transplant rejection. Antagonists, including small molecules and monoclonal antibodies, are being developed to block receptor function and reduce inflammation.

Other names

C5AR1CD88Complement Component 5A Receptor 1

Selective inhibition of pro-inflammatory signaling by blocking C5a binding and downstream signaling pathways (e.g., Gαi, ERK1/2, calcium mobilization, Rho activation)