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Target intelligence / Profile preview
Complement C1 complex (C1)
- Target
- C1
- Molecular classification
- Enzyme, Serine protease, Multi-subunit protein complex
01
Overview
The C1 complex is the first component of the classical complement pathway, composed of C1q, C1r, and C1s subunits. It initiates the pathway upon binding to antibody-antigen complexes, leading to activation of C1r and C1s serine proteases, which cleave downstream complement components and propagate the complement cascade. Dysregulation can lead to autoimmune and inflammatory diseases.
- Other names
- Complement component 1C1qrs complex
02
Mechanism of action
Inhibition of C1r and C1s serine protease activity; preventing cleavage of downstream complement components C4 and C2
03
Biological functions
Immune responseComplement activation (classical pathway)Pattern recognitionInitiation of inflammation
04
Disease associations
Autoimmune diseasesInflammationHereditary angioedemaNeurodegenerative diseases
05
Safety considerations
Risk of infection with C1 inhibitorsThrombotic eventsHypersensitivity reactions
06
Interacting drugs
C1 esterase inhibitor (CINH)
3 more in the full profile.
07
Biomarkers
C4 levelsC1q levelsAutoantibodies against C1q
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