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Target intelligence / Profile preview
Complement C1q (None)
- Target
- None
- Molecular classification
- Glycoprotein, C1q-TNF superfamily
01
Overview
Complement C1q is a large hexameric glycoprotein that serves as the recognition subcomponent of the classical pathway of complement activation. It binds to a variety of ligands, including antibodies, pathogen-associated molecular patterns, and apoptotic cells, triggering the complement cascade. Beyond complement activation, C1q plays roles in immune cell modulation, apoptotic cell clearance, and tissue homeostasis. Deficiency in C1q is associated with autoimmune diseases like systemic lupus erythematosus.
02
Mechanism of action
N/A
03
Biological functions
Complement activationLigand bindingOpsonizationPhagocytosis enhancementCell lysisInflammationModulation of immune cell functionsClearance of apoptotic cellsTissue homeostasisDevelopment
04
Disease associations
Autoimmune diseasesSystemic lupus erythematosusInfection
05
Safety considerations
Potential for off-target effects due to broad ligand bindingRisk of exacerbating inflammatory responses if complement activation is not properly controlled
06
Interacting drugs
Anti-inflammatory drugs
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